Without complete surrender to Krishna the living entities do not attain complete fortune. If Krishna is not in our remembrance at every step, at every moment, and during every activity, we will certainly be misguided.

If we maintain the conception of "I and mine" on the strength of the knowledge we have gained through our senses, we will be baffeled in the end. If we are covered by the misconception that we are enjoyers and this material world is meant for our enjoyment, the we will certainly become degraded.
We are souls and this material world is dead matter. "Matter" is that which we can enjoy. Forgetting our constitutional position we are controlled by false ego, imagining ourselves enjoyers and all matter meant for our enjoyment. When false ego peaks, then the sinful conception "I am almighty God" ruins us. If we are bewildered by our own apparent greatness, then we should know that our advancement has been totally obstructed.